MTHFR at the Crossroads: Genetic Variants, Metabolic Disruption, and Clinical Consequences
Learn how MTHFR gene variants 677C→T and 1298A→C alter folate pathways, elevate homocysteine, and shape risk for heart, brain, and reproductive disorders.
The early detection of folate receptor autoantibodies is necessary because it can lead to timely diagnosis and appropriate management of conditions associated with these autoantibodies. Folate receptor autoantibodies have been found in Cerebral Folate Deficiency Syndrome, Autism Spectrum Disorders, Schizophrenia, Depression and Neural Tube Defects, among other neurodevelopmental disorders.
FRAT® - developed in the lab of Dr. Edward Quadros at the State University of NY (SUNY Downstate) is the only assay available that can screen for BOTH blocking and binding folate receptor autoantibodies. FRAT®, as published in the New England Journal of Medicine, and used in numerous clinical trials, is the world’s leading diagnostic to detect these specific autoantibodies.
The timely initiation of appropriate treatment, such as alternate reduced folates and/or dietary adjustments, may lead to optimal outcomes and improved overall prognosis for the individual.
As with any medical test, the interpretation of the results and the subsequent treatment plan should be discussed with a qualified healthcare professional.
We continuously research the significance of folate receptor autoantibodies and their implications in various neurodevelopment and neuropsychiatric disorders.
Learn how MTHFR gene variants 677C→T and 1298A→C alter folate pathways, elevate homocysteine, and shape risk for heart, brain, and reproductive disorders.
Understand how Leucovorin and 5-MTHF differ in treating Folate Receptor Autoantibodies and why Leucovorin may work better in Cerebral Folate Deficiency.
Discover why some autistic children seem overly friendly and how gentle guidance can help them build safe, confident social connections.
Discover why screening for folate receptor autoantibodies (FRAAs) is vital in diagnosing and treating neurological and neurodevelopmental disorders effectively.
Cracking the Folate Code explores how genetic variants in folate metabolism influence cardiovascular risk, birth outcomes, and autism spectrum disorder.
Discover how Leucovorin targets core autism symptoms by addressing folate receptor autoantibodies (FRAAs) and improving language, behavior, and cognition in ASD.